One capsule that replaces a whole stack sounds convenient — but does it actually deliver?

Pure Encapsulations O.N.E.™ Multivitamin is positioned as a once-daily, hypoallergenic formula for men and women 18+ with highly bioavailable vitamins, fully chelated trace minerals, and an antioxidant bundle (CoQ10, alpha-lipoic acid, carotenoids).

Brand positioning: a practitioner-grade, additive-free multivitamin coming from a company known for clean, allergen-conscious formulations.

Core thesis: O.N.E. is strongest where most multis are weakest — activated B-vitamins and meaningful CoQ10 inclusion — but it omits vitamin K and leaves out bulky minerals like magnesium, calcium, and iron. Those are deliberate design choices you need to understand to use this product intelligently.

Target reader: bio-hackers, people with MTHFR variants, health-conscious professionals, clinicians and “educated consumers” who want research-anchored clarity rather than marketing fluff.

Most multivitamins either skip CoQ10 completely or sprinkle in token 5–30 mg doses that look good on the label but do little in real life. Pure Encapsulations O.N.E. goes further with a total of 50 mg CoQ10 per capsule, part of which is included as a MicroActive® CoQ10–cyclodextrin complex with sustained release.

Why this matters:

• CoQ10 is poorly absorbed in its basic crystalline form and strongly dependent on fat intake.
• MicroActive® technology embeds CoQ10 in a cyclodextrin matrix, improving water dispersibility and providing a more gradual, 24-hour release profile.
• Human data (sponsor-linked) suggest roughly 3×–3.7× higher bioavailability versus standard crystalline CoQ10 and a more consistent plasma response across users.

For a one-a-day multivitamin, this is an unusually serious approach to CoQ10, not just label decoration.

Who actually needs this?

• 40+ or people on statins: endogenous CoQ10 production declines with age, and statins further deplete it. A 50 mg, better-absorbed dose is not a replacement for dedicated 100–200 mg CoQ10 protocols in disease states, but it is a meaningful baseline for status support.
• Under 40, healthy: think of this as maintenance-level mitochondrial and antioxidant support, not as a performance or therapy dose. If your baseline CoQ10 is adequate, the effect is likely subtle.

Takeaway: among once-daily multis, O.N.E. is one of the few where the CoQ10 line is not purely cosmetic. You still may want a separate CoQ10 product for targeted therapy, but as part of a daily base multi, 50 mg with a sustained-release delivery system is a genuine differentiator.

O.N.E. leans heavily into activated / methylated B-vitamins, and Pure does something most brands don't: it discloses the exact proportions of active forms.

• Riboflavin: 3 mg total, declared as vitamin B2 with 43% as riboflavin-5'-phosphate (R5P).
• Vitamin B6: 4 mg total, declared as pyridoxine HCl with 38% as pyridoxal-5'-phosphate (P5P).
• Folate: provided entirely as Metafolin® (L-5-MTHF), not synthetic folic acid.
• Vitamin B12: a high dose of 500 mcg methylcobalamin (active B12).

Why this matters for MTHFR and methylation:

• L-5-MTHF bypasses common MTHFR bottlenecks that can limit conversion of folic acid into active folate.
• Methylcobalamin is directly usable for methylation cycles and homocysteine metabolism.
• P5P and R5P partially replace the need for the liver to activate B6 and B2, which can be useful in people with compromised liver function or genetic variants affecting these steps.

Label transparency as a trust signal: most brands will say “with active B6” without telling you if that's 5% or 95% of the dose. Here you see that a meaningful fraction is activated (38–43%), while the rest is conventional but still fully usable. That is honest, clinically useful information.

Bottom line: if you have confirmed or suspected MTHFR variants or simply want a multi that doesn't rely on folic acid at all, O.N.E. is architected in the right direction. It’s not a “mega-methylation” formula, but it avoids the biggest folate/B12 pitfalls that still plague mass-market multis.

Minerals are where most one-a-day formulas either overpromise or under-deliver. O.N.E. makes a few very deliberate decisions.

The good: premium where it actually counts

• Molybdenum 75 μg as TRAACS® molybdenum glycinate chelate. This is a fully chelated Albion form, chosen for better tolerability and predictable absorption. Molybdenum is a cofactor for detox enzymes (e.g., sulfite oxidase), and using a premium chelate here makes sense for sensitive, “functional medicine” users.
• Selenium as selenomethionine: an organic, well-absorbed form that integrates into body proteins.
• Chromium as polynicotinate or similar complex: again, a higher-grade form than generic chromium chloride, often used for insulin and glucose support in the literature.

The compromise: zinc as citrate, not bisglycinate

• 25 mg zinc citrate is a solid, absorbable form. Human data suggest zinc citrate is at least as bioavailable as zinc gluconate and superior to oxide.
• However, some premium lines now standardize on zinc bisglycinate (a TRAACS chelate) for gentler GI tolerance and potentially better absorption in compromised gut function.
• Given the tight space in a one-a-day capsule and the already high 25 mg dose, choosing citrate likely reflects a cost and capsule-volume trade-off, not a complete disregard for quality.

The invisible big minerals: magnesium, calcium, iron

• No magnesium, no calcium, no iron. O.N.E. does not attempt to provide macro-minerals. To put 200–300 mg of elemental magnesium or 500–800 mg of calcium into a single capsule would be physically impossible without displacing everything else.
• Iron-free by design: safer for men and post-menopausal women, and easier to pair with a separate, individualized iron supplement when indicated rather than blanket-dosing everyone.
• No copper: with 25 mg zinc, some practitioners like to add copper, others do not. Pure chooses to leave copper out, assuming diet will cover it or that copper will be handled separately if needed.

In practice: expect O.N.E. to cover trace minerals intelligently (zinc, selenium, chromium, molybdenum, iodine, manganese, boron) while intentionally steering clear of the bulky macro-minerals. You will likely need a separate magnesium supplement and, depending on your context, possibly calcium or iron.

One of the most striking design choices is that O.N.E. contains no vitamin K at all — no K1 and no K2 (MK-4/MK-7). This is unusual in the current premium-multi landscape, where D3+K2 combos are trending.

Why would a brand leave vitamin K out?

• Medication compatibility: Vitamin K directly interacts with vitamin-K antagonist anticoagulants like warfarin. Even modest, inconsistent K intake can destabilize INR. A K-free multi is simply easier for clinicians to integrate into protocols for these patients.
• Universal baseline: dietary K intake from green vegetables and other foods is often sufficient for healthy adults; Pure may be assuming a reasonably K-sufficient diet for the “average” user.

But what about D3 synergy and bone health?

• O.N.E. provides 2,000 IU (50 μg) vitamin D3, which many people legitimately need.
• Some clinicians prefer to pair this with vitamin K2 to support calcium handling (moving calcium into bone rather than soft tissues). For a person not on anticoagulants and with low dietary K, adding K2 via a separate supplement may be appropriate.

How to interpret this as a consumer:

• If you are on or may go on warfarin or other vitamin-K antagonists, a K-free multi is a feature, not a bug — but still discuss any supplement use with your prescribing physician.
• If you are otherwise healthy and using O.N.E. for general D3-backed support, consider your dietary K intake and talk to your practitioner about adding a separate K2 product instead of expecting it inside the multivitamin.

Net effect: the absence of vitamin K is a clinical design decision that widens compatibility for certain patients but shifts the responsibility for K management onto separate diet/supplements for everyone else.

Beyond vitamins and core minerals, O.N.E. adds a handful of “hero” phytonutrients and antioxidants: lutein, zeaxanthin, lycopene, alpha-lipoic acid (ALA), inositol, CoQ10. Not all of them are dosed at levels seen in clinical trials.

Lutein & zeaxanthin — eye support, but sub-AREDS doses

• O.N.E. contains 3 mg lutein and 0.5 mg zeaxanthin.
• AREDS2 protocols for age-related macular degeneration used around 10 mg lutein + 2 mg zeaxanthin daily.
• So here you get roughly one-third to one-quarter of “research-grade” intake — helpful as a top-up, but not equivalent to an eye-specific formula.

Takeaway: good for incremental macular pigment support if your diet is low in greens, not a stand-alone AMD strategy.

Alpha-lipoic acid (ALA) 50 mg — light antioxidant, not clinical dosage

• Clinical studies on ALA for diabetic neuropathy, glucose metabolism, or metabolic syndrome generally use 300–600 mg/day and sometimes higher.
• 50 mg/day is an order of magnitude lower: think of it as modest antioxidant support, not a targeted therapeutic tool.

Takeaway: safe, but don’t expect neuropathy or insulin-resistance outcomes from this dose alone.

Inositol 25 mg — biochemically relevant, practically negligible

• Effective inositol protocols for PCOS and mood/panic disorders sit in the 2–18 grams/day range.
• O.N.E. provides 25 mg — i.e., 0.025 g — which is tiny compared to what is naturally present in a modest whole-food diet.

Takeaway: inositol here is more of a symbolic inclusion to round out the B-like complex rather than a dose with independent clinical impact.

Lycopene & “extra” carotenoids

• Lycopene 0.5 mg is far below levels studied for prostate or cardiovascular benefits (often 5–15 mg/day).
• Still, it adds a small increment to overall carotenoid antioxidant load.

Bottom line on bonus actives: aside from CoQ10 (which is dosed meaningfully for a multivitamin), these extras function as low-grade background support. They improve the nutrient density of the capsule and may be helpful over long timeframes, but they do not replicate targeted protocols used in ophthalmology, neurology, or endocrinology.

On our platform we score products by a proprietary Bioavailability Index (BI) that weights each ingredient by:

• its chemical form (e.g., oxide vs glycinate vs methylated vs active coenzyme);
• the quality of evidence for that form's absorption and bioactivity;
• and its relative share of the total nutrient load in the formula.

For Pure Encapsulations O.N.E. Multivitamin, our current BI score is:

BI = 4.33 / 5 — “High”

Why the score is high

• Widespread use of active or optimized vitamin forms (L-5-MTHF, methylcobalamin, partial P5P/R5P, natural d-alpha tocopherol succinate).
• Quality mineral forms for several key trace elements (TRAACS® molybdenum glycinate chelate, selenomethionine, chromium polynicotinate, iodine as potassium iodide).
• Clinically relevant CoQ10 inclusion (50 mg with MicroActive® component) rather than a token sprinkle.
• Clean excipient profile — low interference with absorption from binders, colorants or problematic fillers.

Why it's not “perfect”

• Zinc citrate is acceptable and absorbable but not as ideal (for some users) as a fully chelated bisglycinate.
• No magnesium, calcium or iron — this is not a complete micronutrient solution and requires stacking with other products for many users.
• “Bonus” actives like lutein, ALA and inositol are present but underdosed relative to clinical literature; they don’t raise the BI much because their real-world impact at those levels is uncertain.

Important: BI is not a direct measure of clinical efficacy or outcome. It is a structured way to compare ingredient quality and form choices across products. In that sense, O.N.E. performs very well and legitimately qualifies as a high-bioavailability, practitioner-grade multivitamin.

Who O.N.E. is best suited for

• Adults (18+) of any sex who want a once-daily, practitioner-grade multivitamin with cleaner forms and excipients.
• People with suspected or confirmed MTHFR variants who want folate as L-5-MTHF instead of folic acid and methyl-B12 instead of cyanocobalamin.
• Users on vitamin-K antagonist anticoagulants (e.g., warfarin), for whom a K-free multi is often preferable — always under medical supervision.
• Health-conscious professionals and “bio-hackers” looking for a multivitamin that does more than cover the RDA and includes CoQ10 and active B-vitamins in one capsule.
• Allergy- and sensitivity-prone individuals, who benefit from Pure's hypoallergenic, additive-minimal formulation.

Who may need a different approach or extra stacking

• Pregnant or trying-to-conceive women: this is not a prenatal; vitamin A is present, and there is no iron or vitamin K. A dedicated prenatal formula is more appropriate.
• People with known iron deficiency, severe magnesium deficiency, or high calcium needs: O.N.E. deliberately omits meaningful amounts of these minerals, so they will need separate, individualized supplementation.
• Patients with specific conditions (e.g., AMD, diabetic neuropathy, PCOS, major depression) expecting therapeutic effects from lutein, ALA, or inositol — O.N.E.’s doses do not match clinical protocols.

General safety notes

• The formula uses forms and doses that are generally recognized as safe for adults, but it is not a substitute for medical care.
• Always discuss new supplements with your healthcare provider if you take prescription medications (especially anticoagulants, anti-hypertensives, diabetes drugs or anticonvulsants).
• If you have a history of fat-soluble vitamin toxicity, monitor serum levels of vitamins A and D with your clinician when adding any high-potency multi.

In practice: O.N.E. works well as a high-quality nutritional “base layer” for many adults, as long as they understand its gaps (no K, no magnesium, no iron, limited calcium) and are prepared to fill those intentionally.

Pure Encapsulations O.N.E. Multivitamin is not a generic “one-a-day” — it is a practitioner-style, high-bioavailability multivitamin that leans into methylated B-vitamins, a meaningful CoQ10 inclusion, and a hypoallergenic design.

Where it clearly delivers

• Ingredient quality: active forms (L-5-MTHF, methyl-B12, partial P5P/R5P), selenomethionine, TRAACS® molybdenum, plus MicroActive® CoQ10 give it a legitimately high-quality profile.
• Label transparency: disclosing the exact percentage of activated B-vitamins is rare and clinician-friendly.
• Clean excipients & once-daily convenience: easy to adhere to and suitable for sensitive users.

Where it makes conscious compromises

• No vitamin K: advantageous for people on certain anticoagulants, but suboptimal for others unless K/K2 is added separately.
• No magnesium, calcium or iron: forces you to think in terms of a stack rather than a single “everything pill”.
• Zinc as citrate, not bisglycinate: a reasonable but not gold-standard choice in an otherwise premium-leaning formula.
• Under-dosed “bonus” actives: lutein, ALA, inositol and lycopene are present, but not at the levels seen in disease-focused trials.

Scorecard

• Quality of forms: 4.5 / 5
• Formula completeness: 4 / 5 (strong micro coverage, macro minerals intentionally left out)
• Bioavailability Index (internal): 4.33 / 5 (High)

Final assessment: if you want a professional-grade, once-daily multivitamin that gets the fundamentals right (especially methylation support and CoQ10) and you are comfortable layering magnesium, vitamin K2, and possibly iron or calcium on top, Pure Encapsulations O.N.E. is a very strong candidate. If you want a single pill that solves all micronutrient and condition-specific needs, this isn’t it — and realistically, no honest one-a-day is.