SFR assesses the declared nutrient forms; this score is not a measurement of absorption.
Pure Encapsulations, O.N.E.™ Multivitamin, 60 Capsules
Pure Encapsulations O.N.E.™ is a once-daily multivitamin with methylated folate and B12 plus a CoQ10 blend. It provides selected trace minerals, with no declared calcium or magnesium contribution.

Key Facts
Fast product-level facts before the full review.
The bottle contains 60 servings, providing 60 days at the stated daily dose.
The label also specifies activated forms as 43% of B2 and 38% of B6.
Provides 250% of the listed Daily Value.
Provides 227% of the listed Daily Value.
The label attributes 18% of total CoQ10 to the sustained-release MicroActive complex.
Calcium and iron also have no separately declared nutrient amounts.
Pure Encapsulations O.N.E. Multivitamin Review (60 Capsules)
Supplement Facts & Bioavailability
Full ingredient list with serving amounts, Daily Values, and bioavailability levels.
| Ingredient | Amount Per Serving | % Daily Value | Bioavailability Level | ||
|---|---|---|---|---|---|
| Vitamin A (as vitamin A acetate and 73% beta carotene) | 1,125 mcg | 125% | Up. Medium | ||
Up. Medium | |||||
| Vitamin C (as ascorbic acid) | 180 mg | 200% | High | ||
High | |||||
| Vitamin D (as cholecalciferol) (D3) | 50 mcg (2,000 IU) | 250% | High | ||
High | |||||
| Vitamin E (as d-alpha tocopherol succinate) | 20 mg | 134% | Up. Medium | ||
Up. Medium | |||||
| Thiamin (as thiamin HCl) (B1) | 3 mg | 250% | High | ||
High | |||||
| Riboflavin (as vitamin B2 and 43% riboflavin 5'phosphate (activated b2)) | 3 mg | 231% | Up. Medium | ||
Up. Medium | |||||
| Niacin (as niacinamide) | 20 mg | 125% | High | ||
High | |||||
| Vitamin B6 (as pyridoxine HCl and 38% pyridoxal 5' phosphate (activated b6)) | 4 mg | 235% | Up. Medium | ||
Up. Medium | |||||
| Folate (as Metafolin®, L-5-MTHF) | 667 mcg DFE (400 mcg L-5-MTHF) | 167% | Superior | ||
Superior | |||||
| Vitamin B12 (as methylcobalamin ) | 500 mcg | 20,833% | High | ||
High | |||||
| Biotin | 300 mcg | 1,000% | High | ||
High | |||||
| Pantothenic acid (as calcium pantothenate) (B5) | 10 mg | 200% | High | ||
High | |||||
| Iodine (as potassium iodide) | 150 mcg | 100% | High | ||
High | |||||
| Zinc (as zinc citrate) | 25 mg | 227% | Medium | ||
Medium | |||||
| Selenium (as selenomethionine) | 70 mcg | 127% | High | ||
High | |||||
| Manganese (as manganese citrate) | 2 mg | 87% | High | ||
High | |||||
| Chromium (as chromium polynicotinate) | 200 mcg | 571% | High | ||
High | |||||
| Molybdenum (as TRAACS® molybdenum glycinate chelate) | 75 mcg | 167% | High | ||
High | |||||
| Boron (as boron glycinate) | 1 mg | * | High | ||
High | |||||
| Inositol | 25 mg | * | High | ||
High | |||||
| Coenzyme Q10 (as CoQ10 and as 18% from sustained-release MicroActive Q10-cyclodextrin complex) | 50 mg | * | Superior | ||
Superior | |||||
| Alpha lipoic acid | 50 mg | * | High | ||
High | |||||
| FloraGlo® Lutein | 3 mg | * | High | ||
High | |||||
| Zeaxanthin | 500 mcg | * | Up. Medium | ||
Up. Medium | |||||
| Lycopene | 500 mcg | * | Medium | ||
Medium | |||||
| *Daily Value (DV) not established | |||||
One capsule, selective nutrient coverage
Pure Encapsulations O.N.E. Multivitamin combines a broad vitamin panel, selected trace minerals and CoQ10 in a one-capsule daily routine. Its clearest structural strengths are the simple serving and the disclosure of specific B-vitamin forms and mixtures.
The main tradeoff is nutrient coverage. Calcium and magnesium are not declared as nutrients, so the formula fits someone seeking this particular vitamin and trace-mineral combination rather than comprehensive mineral coverage.
Dose priorities and mineral coverage
The doses are not uniformly close to 100% Daily Value. Most listed vitamins provide 125-250% DV, but B12 stands out at 500 mcg, or 20,833% DV. That makes the formula a different choice from a multivitamin intended to stay near the listed DVs throughout. A large percentage describes the amount relative to the DV; it does not by itself establish greater benefit, individual need or toxicity.
The mineral panel is selective, but that does not mean every included mineral has a small dose. Zinc provides 25 mg, or 227% DV, while magnesium, calcium and iron have no declared nutrient contribution. For a buyer prioritizing those omitted minerals, the vitamin doses do not resolve that coverage gap.
Methylated forms and partly activated B-vitamins
For buyers specifically looking for methylated folate and B12, the label names Metafolin L-5-MTHF and methylcobalamin. These identities let you check that preference directly without treating an unspecified active-vitamin claim as a description of the whole B-vitamin panel.
B2 and B6 are mixtures. The label attributes 43% of B2 to riboflavin 5-phosphate and 38% of B6 to pyridoxal 5-phosphate. The useful distinction is that the activated forms make up part of each total, so neither vitamin should be described as supplied exclusively in its activated form.
CoQ10: 50 mg total, with a partial MicroActive component
The 50 mg figure is total CoQ10, not 50 mg entirely from MicroActive. The label attributes 18% of the total to the sustained-release MicroActive Q10-cyclodextrin complex, alongside the other declared CoQ10 component.
This distinction matters when interpreting the delivery claim: the branded sustained-release component represents part of the CoQ10 dose. Its presence alone does not demonstrate an absorption advantage or a clinical result for the complete multivitamin.
Daily use, dietary claims and label warnings
The manufacturer's directions are one capsule daily with a meal. At that dose, the 60-capsule bottle provides 60 days of supply. The stated audience is adults aged 18 and older. Store in a cool, dry place.
The manufacturer identifies the product as vegetarian and reports gluten-free certification by the Gluten-Free Certification Organization (GFCO). The supplied materials do not include independent registry confirmation or product-specific testing results.
The label instructs people who are pregnant or lactating, have a health condition, or take medication to consult their health professional before use. Keep out of the reach of children and use only if the safety seal is intact.
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Frequently Asked Questions
How do you take Pure Encapsulations O.N.E., and how long does the bottle last?
The manufacturer's directions are one capsule daily with a meal. At that dose, the 60-capsule bottle provides 60 days of supply.
Does Pure Encapsulations O.N.E. use methylated folate and B12?
Yes. The label lists folate as Metafolin L-5-MTHF and vitamin B12 as methylcobalamin. These identify the folate and B12 forms; they do not mean that every B-vitamin is supplied entirely in an activated form.
Does Pure Encapsulations O.N.E. contain vitamin K or K2?
No vitamin K is listed in the Supplement Facts, including K1 or K2. This formula therefore does not provide a D3 + K2 combination.
Does Pure Encapsulations O.N.E. contain magnesium, calcium or iron?
The Supplement Facts do not declare magnesium, calcium or iron as nutrients. Calcium pantothenate appears as the source of vitamin B5; it is not a separately quantified calcium serving.
Does Pure Encapsulations O.N.E. contain copper?
Copper is not listed in the Supplement Facts. If copper is one of the nutrients you want included in your multivitamin, this formula does not declare a contribution.
How much CoQ10 does Pure Encapsulations O.N.E. contain?
Each capsule contains 50 mg total CoQ10. The label attributes 18% of that total to the sustained-release MicroActive Q10-cyclodextrin complex; the full 50 mg should not be described as MicroActive CoQ10.
Sources
Disclaimer
The information provided on this website is for informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a healthcare professional for any health-related questions or concerns.